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Simvastatin is the most lipophilic of the statins, which may allow it to more easily cross the blood-brain barrier. "Lipophilic" means fat-loving, and the brain is composed largely of fats.
However, any direct affects on the brain has generally been believed to be related to the ability of statins to cross what is known as the 'blood-brain-barrier'. An agent's ability to breach the blood brain barrier is traditionally thought to be related to several factors, including its affinity to fat or water.
The mechanisms involved may include blood-brain barrier injury, the influence on small blood vessels in the brain, the influence on amyloid deposition, and a neuroprotective effect.
We recommend that future human studies of this important therapeutic topic (1) take the blood-brain barrier permeabilities of statins into account when analyzing results, (2) include specific analyses of the effects on low- and high-density lipoprotein cholesterol, and, most important, (3) conduct statin treatment trials solely in patients with.
Dysregulation of the blood-brain barrier (BBB) and transendothelial migration of immune cells are among the earliest central nervous system changes partaking in lesion formation in both multiple.
P-gp is a major component of the blood-brain-barrier 29 and it is located in different brain cell types including neurons P-gp could act as a transporter both at the blood-brain barrier and neuronal cells.
So, overall, it seems unlikely that statins that don't cross the blood-brain barrier would increase your risk for Alzheimer's disease. As for what can help prevent Alzheimer's-associated brain degeneration, one possibility is to protect your gut-brain axis.
Statins that cross the blood-brain barrier are called "lipophilic" statins. Simvastatin and atorvastatin are the most lipophilic while pravastatin and Crestor are the least. The statins that cross the blood-brain barrier have more reported memory and "fuzzy head" problems. We identify several confounding factors among the human studies, including differing blood-brain barrier permeabilities among statins, the stage in AD at which statins were administered, and the drugs' pleiotropic metabolic effects, all of which contribute to the substantial variability observed to date.
Statins as Neuroprotectants: A Comparative In Vitro Study of Lipophilicity, Blood-Brain-Barrier Penetration, Lowering of Brain Cholesterol, and Decrease of Neuron Cell Death. Read "Statins as Neuroprotectants: A Comparative In Vitro Study of Lipophilicity, Blood-Brain-Barrier Penetration, Lowering of Brain Cholesterol, and Decrease of Neuron Cell Death, Journal of Alzheimer's Disease" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Fat soluble statins can easily cross the fatty, blood-brain barrier and penetrate into the nerves. There are a few issues here: Is it a direct toxic effect of the statins on nerves that increases. That greater penetration into your brain's cells may result in additional anti-oxidant and anti-inflammatory benefits that slow or stop the development of Parkinson's, Dr. Lin adds.